Season 1, Episode 7: Fidelity
Original Air Date—28 December 2004
A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
Two men are out jogging — one of them returns back to his wife and discovers her dead asleep and brings her to the clinic. The doctors are puzzled by her symptoms. They consider everything from tumors to breast cancer to rabbit fever. When all the treatments fail, House concludes she has African sleeping sickness. However, neither the woman nor her husband could possibly have ever been to Africa. The woman will die without the proper treatment, but neither one will admit to having an affair.